![]() By exploring the genetic determinants of waist-to-hip ratio in this study, important insights into the mechanisms that contribute to body fat distribution were uncovered helping identify potential therapeutic targets for abdominal obesity, like INHBE. “There is a well-established causal link between increased waist-to-hip ratio and a person’s risk of cardiometabolic conditions. ![]() It added that it plans to pursue a development candidate for INHBE and its gene product, Activin E, leveraging its liver IKARIA platform.ĭr Paul Nioi, vice president, discovery and translational research, and the leader of Alnylam’s human genetics group, commented on the development. The published data shows that rare mutations in the liver-expressed INHBE gene are associated with lower waist-to-hip ratio adjusted for body mass index, (WHRadjBMI), a surrogate for abdominal fat that is causally linked to type 2 diabetes and coronary heart disease.įindings support the potential of INHBE to be evaluated as a novel therapeutic target for the treatment of cardiometabolic disease, said the RNAi therapeutics developer. The discovery leveraged sequencing data from more than 360,000 individuals in UK Biobank, and was published in Nature Communications.
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